ectopic recombination造句

• The role of transposable elements in ectopic recombination is an area of active inquiry.
• However, according to one proposed model, ectopic recombination might serve as an inhibitor of high transposable element copy numbers.
• Transposable elements repetitious sequences of DNA that can insert themselves into any part of the genome can encourage ectopic recombination at repeated homologous sequences of nucleotides.
• Since ectopic recombination is generally deleterious, anything that increases its odds of occurring is selected against, including the aforementioned higher copy numbers and longer lengths.
• The subtelomeric repeats can rescue chromosome ends when telomerase fails, buffer subtelomerically located genes against transcriptional silencing and protect the genome from deleterious rearrangements due to ectopic recombination.
• This model, however, can only be applied to single families of transposable elements in the genome, as the probability of ectopic recombination occurring in one TE family is independent of it occurring in another.
• It follows that transposable elements that are shorter, transpose themselves less often, and have mutation rates high enough to disrupt the homology between transposable element sequences sufficiently to prevent ectopic recombination from occurring are selected for.